Tag: brain hacking
Quartz Obsession on Neurostimulation
Total coincidence, this just came out today
I especially like this section, on brain hacking history:
~43 AD: Roman physician Scribonius Largus pens Compositiones Medicamentorum, in which he describes using the bioelectric torpedo fish to treat headache and gout.
11th century: Persian physician Ibn-Sidah suggests using electric catfish to treat epilepsy.
1783: An electrical accident causes physician Jan Ingenhousz to partially lose his memory, but it also makes him strangely happy. In a letter to Benjamin Franklin, with whom he corresponded, Ingenhousz calls for clinical trials into the use of electricity to improve mood.
1890: William James first suggests that the human brain can change over time in The Principles of Psychology. Previously, it was believed that brains were fixed with innate abilities, and that you basically couldn’t teach an old dog new tricks.
1938: Electroshock therapy is introduced by Italian psychiatrists Ugo Cerletti and Lucio Bini.
1948: Polish neuroscientist Jerzy Konorski coins the term “neuroplasticity,” a reference to the malleable nature of the brain.
1964: The first academic article showing cognitive benefits of neurostimulation is published.
1987: French neurosurgeon Alim Louis Benabid uses deep-brain stimulation to calm the tremor in a patient with Parkinson’s.
2000: Eric Kandel wins the Nobel Prize in physiology or medicine for his work showing how nerve cells communicate using electrical and chemical signals, prompting wider interest in neuroplasticity.
2017: The FDA approves the NSS-2 Bridge, the first electric stimulation device approved to treat opioid withdrawal.
China’s Race To Hack The Brain
We’ve been talking about Elon Musk and Bryan Johnson and their efforts to better understand our gray matter … but this is an international endeavor, and I just read about this guy…
Kernel: Commercializing Hacking of the Human Brain
Kernel is one of the two companies (the other being Elon Musk’s Neuralink) that’s working with researchers on brain-computer interfaces. We had an intro call this morning so I could learn what they’re up to. Loose notes:
Speaking with Alanna & Shayna, the communications team at Kernel. They run all of Brian’s comms and marketing for Kernel and for the VC he runs and for his thought leadership.
Foundational insight — everything the world looks like frlows from the capabilities and limitations of the human brains. how we understand each other, how we understand the world, the awesomeness that is the human brain and the evolutionary limitations that are there.
Kernel is somewhat unique in the space in that we’re not starting from a “how to tackle disease” or “move their bodies again” but starting from a place of “how do we expand cognition” with the understanding that once we understand how to do that then we can understand how to tackle problems. We’re starting from the other side, which is there’s so much potential here. How do we build on potential. Solutions will come from that.
Organizing principle is build on understanding. We have very little understanding of how the brain works right now. How do all elements come together to make us who we are? Think about it like FitBit when we learned that we could measure biometric data like heart health and sleep. We’re not at that place in the brain, and that’s partly because we don’t understand how it all works. Right now the tools for measuring and reading it are rudimentary. Anything we do have is enormous and have to be institutionalized, like fMRI.
FOCUSES
- is it possible to have non-invasive (wearable) for our brains? What are the tools for read out, the neuroscience of readout, with the physics of miniaturization?
- Once you figure out how to read, then it’s can you write? Can you deliver nudges to the brain? Is there a way to know, based on something you’re wearing, when you’re dwelling on something unsuccessfully? Would it be possible to nudge your thinking inside your brain? What are most useful and enhancing modes?
KERNEL offices and labs are in LA, in Venice.
Smaller operation in Boston
Hire researchers … Hired the pre-eminent neurophysicist to come in-house and partners and advisers from mostly from
TIMING
Right now what’s going on is entirely proprietary … off record or would have to hold. Kernel and Neuralink are in a race. Whoever gets the first thing that can go to market. Embargoes are necessary. Hooman the CTO can do the explaining on video. He’s lovely. Really wonderful way of understanding complex things. Center of all kinds of modalities. Can do that in February.
- Documentary is being produced … called I Am Human, a doc about this journey to forge man and machine. Focused on the existing things to market around solving problems. Follows three patients, one with Parkinson’s, one blind and one with paralysis. Then to Brian and what he is doing to enhance himself. Releasing in April in Tribeca. Sending a preview.
- Presently working with the Future of Everything team at WSJ to do a deep dive on a narrower focus on what’s coming to market. What’s the process of coming to market?
Project Update: Human Body Ideas
I’ve spent the past couple of weeks really immersing myself in futurism and people who think about the world on a timeline three decades out. That’s led me to a framework for our areas of inquiry that both holds up for organizing changes of the past — and can stand up to the changing winds of the future: human-centeredness. Each chapter can be organized by a basic human need.
I’m going to start exploring the human body, and what enhancements both biologically and technologically to humans-as-we-know-them will look and feel like by 2050, and the potential consequences and possibilities from that.
From that layer we can build out. From individual human bodies to human-to-human connections, with an exploration on love, sex and connection in 2050. And then further out, to human-to-human-human — communities and cities in 2050, where the urban question and transportation and such can be explored. The questions of economy, and power and governance could then flow from that, into another area of inquiry. But we’ll start with the most basic unit — the human body, and go from there.
So here are few angles I think we could hit for a single “episode” or chapter of this project. Each idea could be its own explainer and then we can piece them together for an episode.
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- Past predictions for the human body, that is, how “futurists” of the 1980s believed humans would operate by our present. Will it need food and water to survive? How long will humans live in 2050? Will genetic disease be eradicated by then? What were PREVIOUS predictions for how humans would be by 2020? (The look back would be a feature of every chapter/episode).
- Everyone wants to live longer, but no one wants to grow old: The focus these days is increasing longevity while avoiding or delaying the stigmata of biological aging. Billions are now being spent to prove that advances in medicine will slow the aging process so that the average 90-year-old will feel as good as today’s 70-year-old. Google’s Calico is in the forefront of these efforts. Other companies have focused on specific diseases, but Calico is targeting the cellular degradation involved in aging that plays a role in most deadly diseases.
- Cryonic preservation: The Cryonics Institute in Michigan has over 100 people in “cryonic suspension” at its facility. SO MANY QUESTIONS. Alcor in Arizona charges $80,000 for “neurocryopreservation” (the head only) and $200,000 for the whole body but this includes all costs and perpetual maintenance. Cryopreservation can be covered by special insurance policies!
- Real time emotional state detection: Facial and tonal recognition analytics will help machine learning systems to detect consumers’ emotional state in real-time. Algorithms will harness your data in order to assess your predicted success at work, how likely you are to bounce around jobs and more. (This would then lead right into the 2050 dating/love chapter, in which future dating is predicated on systems that can read your physiological response to potential partners — you don’t even HAVE to decide!)
- Nanobots for targeted therapies: Teeny tiny robots could become mini-surgeons, squished into a pill that you swallow, under work being led by CSAIL at MIT. Because magnetic fields are able to transmit through our bodies without harming us, future surgeons could ask patients to ingest these nanobots and then direct them magnetically in order to deliver targeted therapies.
- Communicating with thought alone: At the University of Washington’s Center for Sensorimotor Neural Engineering, researchers built a system allowing one person to transmit his thoughts directly to another person. Using electrical brain recordings and a form of magnetic stimulation, one researcher sent a brain signal to another person elsewhere on campus, causing his finger to tap a keyboard. At Duke, researchers at the Center for Neuroengineering built a real-life Iron Man suit, allowing a young man suffering from complete paralysis of his lower body to walk out onto a soccer field and kick the first ball of the 2014 World Cup.
- Computerized Brains, and brain hacking. Devices implanted in your brain could function in two main ways: “Not only send signals to the brain as a means of treatment, but also gather data about the nature of these maladies.” There are several labs currently looking at ways in which computer interfaces will be operating within our brains, and the social implications of it. There is a cybersecurity angle in which brain hacking could become a thing. The hot brain implantation right now is neural lace: a new kind of flexible circuit implanted via injection, a grid of wires only a few millimeters across can insinuate itself with living neurons and eavesdrop on their chatter, offering a way for electronics to interface with your brain activity, perhaps curing diseases like Parkinson’s. (Engineers at Kernel, Charles Lieber at Harvard).
- NOTE: The Bergguen Institute here in LA has a dedicated topic area called “Transformation of the Human,” which we can partner with or report on as they explore the same area. I don’t know where it fits in but I am imagining using them as talking heads or as co-travelers/co-hosts in exploration. I have a visit scheduled with the head of the Transformation of the Human project on October 9. More info:
“Humans have historically defined themselves by contrast to machines and animals, by having language and intelligence, and by the idea of a soul. Just as earlier changes such as the evolution of language, literacy, and better nutrition changed what it means to be human, so are new technologies changing our material realities and thus destabilizing old definitions of the human. We are interested, for example, in artificial intelligence and gene editing, as well as developments in neuroscience, bio-engineering, and interventions into the human microbiome. At the same time, we recognize that changing social and cultural norms are part of the process of redefining of the human, not least as different civilizational traditions inform and challenge each other.”